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Paul 78 interaction 100 thermolysin inhibitors 241 rigid analogs 227 similarity 228 64, 87, 235, 236, 239, thiorphan 235, 236, 237 three-dimensional structures, macromolecules 19 threshold potential thrombin inhibitors similarity 228, 230 thymidine kinase, herpes simplex virus 173 ff 91, 107 results 46 ff steric complementarity fit VALIDATE II approach validation categorical Sale Tadaga 10mg St. Paul chemistry-space metrics 49ff 346 proton transfer complex site-directed mutagenesis thyroxine, isosteric replacement topological QSAR analyses 222 VAMP-PCM approach 139 genetic algorithm 147 van-der-Waals (vdW) interactions attractive 13 van-der-Waals radius 305 autocorrelation 291 descriptors, in WHIM topomeric 370 257 bumpcheck 311 variable influence on projection (VIP) 393 variable selection 19 ff24, 355 ff blind 390 genetic algorithm (Moby Digs program) 370 GOLPE 25 variable subset selection method 370 how to buy Sildigra, see van-der-Waals 4 Verkhivker scoring function 41 VESPA method 142 vibrational frequencies and spectrum 382 VIP, see variable influence on projection Sale Tadaga 10mg St.

Paul virtual fluid 185 virtual library, ChemSpace 218 vitronectin receptor 243, 244 volume measurements, similarity 330 Wallqvist scoring function 40 water molecules, modelling 22 WDI (world drug index) 314, 317 alignment CoMFA fields 218 torsional flexibility optimization 309 rotations 310 Order Edegra, distance mapping 213 ff 216 total surface area 371, 375 toxicity, species differences LSD 237 312 303 64 tetrachlorodioxin 237 transfer of ligand, from solution to binding site 44 transition state theory 119 translation invariance, of WHIM descriptors 357 triangle data trimethoprim 332 233, 235 176 176 4, 163 226 121 valence-bond method 134 VALIDATE scoring function 40, 43 ff, 63, Sale Tadaga 10mg St.

Paul Subject Index 415 Page 220 Page 258 Page 110 Page 240 10 Water-Insoluble Drug Formulation М To simplify this expression, one of two assumptions is ordinarily made regaфrdCinpg.


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